TDS | SDS The 2D1 antibody reacts with human CD45, one of the most abundant hematopoietic markers and one that is expressed on all leukocytes (the Leukocyte Common Antigen, LCA). CD45 is a protein tyrosine phosphatase existing in several isoforms, each being generated and expressed in cell-specific patterns. With its broad cell distribution, CD45 is critical for many leukocyte functions, regulating signal transduction and cell activation associated with the T cell receptor, B cell receptor, and IL-2 receptor. Other forms of CD45, with restricted cellular expression, include CD45R (B220), CD45RA, CD45RB, and CD45RO. The 2D1 antibody is widely used as a marker for human CD45 expression on peripheral blood T cells, B cells, monocytes, macrophages, and NK cells. Name PE Anti-Human CD45 (2D1) Cat. No. 50-9459 Alternative Names Leukocyte Common Antigen, LCA, Ly-5, Hle-1 Gene ID 5788 Clone 2D1 Isotype Mouse IgG1, kappa Reactivity Human Format PE Application Flow Cytometry
